目的 探讨γ-谷氨酰转移酶在评估酒精所致精神障碍患者肝损害中的价值. 方法 对106例男性酒精所致精神障碍患者(研究组)和104名健康体检者(对照组)进行肝功能测定,比较两组谷丙转氨酶、谷草转氨酶、碱性磷酸酶和γ-谷氨酰转移酶检测结果.结果 研究组谷丙转氨酶、谷草转氨酶、碱性磷酸酶和γ-谷氨酰转移酶检测结果均显著高于对照组(P<0.01),研究组γ-谷氨酰转移酶异常者明显多于对照组(P<0.01).结论 γ-谷氨酰转移酶是评估酒精所致精神障碍患者肝功能损害的敏感指标,具有重要的临床意义,应定期监测.、Objective To explore the value of γ-glutamyltransferase (GGT) in the assessment of hepatic lesion of patients with mental disorders due to use of alcohol.Methods Liver function assays were conducted in 106 patients with mental disorders due to use of alcohol (research group) and 104 healthy examinees (control group) and detection results of alanine aminotransferase (AAT), glutamic-oxal(o)acetic transaminase (GOT), alkaline phosphatase (ALP) and GGT compared between two groups.Results The detection results of AAT, GOT, ALP and GGT were all significantly higher (P<0.01) and persons with abnormal GGT more (P<0.01) in study than in control group.Conclusion GGT is a sensitive index to evaluate liver function impairment in patients with mental disorders due to use of alcohol, has great clinical significance, should be routinely monitored.