目的 探讨低分子肝素钠辅助治疗对子痫前期患者凝血功能及肾功能的影响.方法 将92例子痫前期患者采用随机数字表法分为实验组和对照组各46例,两组均给予常规治疗,实验组联合低分子肝素钠治疗.于治疗前后比较两组患者的凝血功能与肾功能. 结果 治疗后两组凝血酶原时间及活化部分凝血活酶时间均显著长于治疗前(P<0.01),实验组显著长于对照组(P<0.05或0.01);两组尿酸、血肌酐及24 h尿蛋白均较治疗前显著降低(P<0.01),实验组较对照组下降更显著(P<0.05).结论 应用低分子肝素钠辅助治疗子痫前期患者,能够改善患者的凝血功能和肾功能,值得临床推广.、Objective To explore the effect of adjuvant low molecular heparin sodium (LMHS) treatment on blood coagulation function and renal function of patients with pre-eclampsia.Methods Ninety-two patients with pre-eclampsia were assigned to experimental and control group of 46 ones each, both groups received routine treatment, and experimental group was plus LMHS.Pre-and post-treatment blood coagulation and renal function were compared between 2 groups.Results Prothrombin and activated partial thromboplastin times of both groups were notably longer after treatment (P<0.01), so were those in experimental than in control group (P<0.05 or 0.01), and changes of fibrinogen and D-dimer had no obvious changes (P>0.05).After treatment uric acid, serum creatinine and 24 hour urine protein of both groups lowered more significantly (P<0.01), so did those in experimental than in control group (P<0.05), and there wasn‘t no significant group difference in urea nitrogen (P>0.05).Conclusion Adjuvant LMHS treatment could improve blood coagulation and renal function of patients with pre-eclampsia.