探讨新发脑梗死患者抑郁症状与认知损害程度及二者的交互关系.方法 将本院68例新发脑梗死患者作为研究对象,根据韦氏成人智力量表评分分为无认知障碍者25例(A组) ,轻度认知障碍者31例(B组) ,中重度认知障碍者12例(C组) .采用汉密顿抑郁量表、蒙特利尔认知评估量表、剑桥老年认知量表中文版及简易精神状态量表对3组患者的抑郁症状与认知障碍进行评估.采用Framingham心血管危险因素评分量表对3组患者血管危险因素进行评分,分析抑郁症状与认知程度的交互关系.结果 本组患者认知障碍程度的主效应在剑桥老年认知量表中文版各子项中均存在显著差异(P＜0 .05或0 .01) ;抑郁症状的主效应在剑桥老年认知量表中文版子项语言、定向力、思维、计算、执行及记忆方面存在显著差异( P＜0 .05或0 .01) .本组患者的抑郁症状与认知程度在思维、语言及知觉存在显著交互关系(P＜0 .01). A组与B组患者在语言、知觉方面表现出抑郁症状与认知障碍的交互关系(P＜0 .05) ;B组与C组在思维方面表现出抑郁症状与认知障碍的交互关系(P＜0 .01).结论 脑梗死患者存在一定程度的抑郁状态与认知损害,二者存在一定的交互关系,且抑郁症状较重者,认知障碍程度较为严重.、Objective To explore the relationship between depressive symptoms and cognitive impairment in patients with new cerebral infarction and their interaction.Methods 68 cases of new cerebral infarction in our hospital were selected as the research objects.According to the Wechsler Adult Intelligence Scale , 25 patients with no cognitive impairment were seen as group A ,31 patients with mild cognitive impair-ment were seen as group B ,and 12 patients with moderate-severe cognitive impairment were seen as group C.The depressive symptoms and cognitive impairment of the three groups were evaluated by HAMD , MoCA ,CAMCOG-C and MMSE.The Framingham Cardiovascular Risk Factors Rating Scale was used to score the vascular risk factors of the three groups ,and the relationship between depressive symptoms and cognitive level was analyzed.Results The main effect of cognitive impairment in this group of patients was significantly different among the sub-items of CAMCOG-C (P＜0.05 or 0.01).The main effects of depressive symptoms were significantly different among CAMCOG-C sub-items as language ,orientation , thinking ,calculation ,execution ,and memory (P＜0.05 or 0.01).There was a significant interaction be-tween depressive symptoms and cognitive level in thinking ,language and perception in this group (P＜0.01).Patients in group A and group B showed an interaction between depression and cognitive impair-ment in language and perception (P＜0.05).Patients in group B and group C showed an interactive rela-tionship between depressive symptoms and cognitive impairment in thinking (P＜0.01).Conclusion There is a certain degree of depression and cognitive impair-ment in patients with cerebral infarction ,and there is a certain interaction between them and those with severe depressive symptoms have a higher de- gree of cognitive impairment.